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Frequently Asked Questions about Pre-implantation Genetic Diagnosis and Pre-implantation Genetic Screening
Naturally, families have many questions and concerns. Often, they are about to start an unfamiliar procedure with little-known terminology. Most likely, you will never anticipate needing such a procedure.Our goal is to help you build a healthy family. Aster IVF & Women Clinic is happy to work with you in an effort to minimise your concerns.When starting this process, many families have similar questions. In order to make the process easier and to assist you in being informed about the procedure, find below the most frequently asked questions about Pre-implantation genetic diagnosis (PGD) and Pre-implantation genetic screening (PGS).
1. How do we know Aster IVF & Women Clinic will be able to help us if you haven’t performed PGD for my specific mutation?
Our Genetics partner Lab is world-renowned for their expertise in designing the necessary probes for testing a number of the most complicated mutations. You can count on us to thoroughly explain how our laboratory will help you.
2. How long will this process take?
Molecular DNA testing is a complicated process. Each test is custom designed specifically for each family. There is a significant amount of preliminary work that is required prior to you actually starting the IVF process. This scientific work varies with the type of disease, the family’s genetic mutations and the steps involved in customizing and optimizing the “molecular spell checkers.” The process of building your customized probe usually takes 2-4 weeks with the ultraPGD platform and 10-12 weeks for traditional PGD.
3. Are costs for PGD included in our IVF fees?
PGD costs are separate from the IVF costs. As with any medical procedure, issues exist when you decide to use in vitro fertilization (IVF) and PGD to help you have a healthy baby. We know you are making important emotional, psychological and financial decisions.
There are many factors that enter into the costs quoted to you: your geographic location, if you have had problems getting pregnant, the type and amount of hormone medication, micro manipulation costs (ICSI, embryo biopsy) and whether your insurance covers all/some of the process.
4. How often is PGD used? Is it only used in a worse-case scenario or can it be used as a preventive measure as well?
Aster IVF & Women Clinic believes that PGD should be used for only the most serious inherited diseases.
5. Will the biopsy hurt the embryo or cause any damage to our baby?
It is not unusual for families to be concerned about the harmful effects a biopsy might have on the embryo. During the last decade, studies have shown that the developing fetus is not harmed as a result of an embryo biopsy. Performing a biopsy on the embryo is crucial to the reliability of PGD. Each cell in an embryo contains that embryo’s entire genetic code. By using the biopsied cell(s) for PGD testing, we are able to analyze as much of the genetic code as necessary in order to determine if the mutation exists in that specific embryo.
6. PGD or PGS?
Preimplantation genetic screening (PGS) is used to perform a general screening of embryos and does not look for a specific disease. PGS uses PGD techniques and technology to identify embryos at risk.
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