Archives: Treatments & Procedures

Failed IVF

Have You Failed IVF?
Couples with infertility problems and those who are undergoing treatment may have faced many frustrations, disappointments and investigations before, during and after IVF treatment.
Once started, IVF treatment can also be physically and emotionally challenging, and certainly waiting for results can be too stressful. Each and every couple has difficulty coping with this stress from time to time, so you can contact us online for a free second opinion if you need to discuss your situation or explore ways of coping that particular situation.

This will certainly help you to ease out the stress and a low level of stress and relaxed mind will help you in achieving success in your treatment. Our Fertility Physicians are available throughout the different stages of your treatment, even during an ongoing IVF cycle.The senior Aster IVF physicians will personally be attending to your cycle and you will not be delegated to junior doctors. The same Aster IVF physicians will supervise every aspect of your treatment so you don’t see different doctors at each visit!

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Ovulation Induction Treatment

It is the production of an egg by a woman who has never produced an egg before or produces eggs infrequently. The stimulation of the ovary by fertility medication is desired and aims at increasing the number of eggs per cycle thereby increasing the chances of pregnancy. Tablets and injections are prescribed in the first ten days of the period and growth of the on-going egg sacs (follicles) is monitored by transvaginal scanning. Once the optimum size of follicles is achieved, medication (Inj hCG) is advised to trigger the release after maturation of egg (ovulation) from the ovarian follicle. This is the fertile period that is to be consummated naturally by timed intercourse or treatments are performed in this fertile period.

IUI (Intrauterine Insemination) – Artificial Insemination

Intrauterine Insemination (IUI) is one of the most commonly used Assisted Reproductive Techniques (ART) to treat infertility. It is the process of placing washed sperms, through the cervix, into the upper uterine cavity. The IUI procedure bypasses the cervix and places sperms directly into the uterus, closer to the fallopian tubes, around the time of ovulation. This way, there is a better chance that more sperm will make their way and reach the egg. In practice this is usually combined with Controlled Ovarian Hyper-stimulation so that there is more than one egg available for fertilization.
For Gynecologists, referring Physicians, Paramedical staff & Patients who want to read more about IUI, please refer to the Monograph on IUI (Jaypee Brothers Medical Publishers) edited by our IVF Consultant & Head Dr. Gautam N Allahbadia. The book is freely available on Amazon worldwide.

IVF & ICSI Process

In Vitro Fertilization (IVF) is a process by which an egg is fertilized by sperm In Vitro or outside the body, in a laboratory. If the sperm fertilizes the egg, an embryo is formed which is allowed to develop in the laboratory and is then transferred into the women’s uterus where it will hopefully implant and develop further.
The main steps in an IVF cycle are:

  • Controlled Ovarian Hyper-stimulation (COH) and Follicular Monitoring.
  • hCG Trigger and Oocyte Retrieval.
  • Oocyte Culture, Insemination and Fertilization in the IVF Laboratory.
  • Embryo Transfer

Intra Cytoplasmic Sperm Injection (ICSI)

It is the best option in cases where the husband’s sample is of low quality or very low quantity, therefore predicting low chances of fertilizing the eggs on their own. It is also the option for cases of failure to fertilize in IVF. In this method sperm is injected inside the cytoplasm of the egg, and once the eggs are fertilized and the embryos cleave, embryos are transferred back to the uterus on day 2, day 3 or day 5 as in IVF-ET.

ICSI is the last resort for severe male factors including obstructive azoospermia (absence of sperms in semen), in which sperm may also be retrieved surgically from either the epididymis (PESA) or from the testes (TESA/TESE). An azoospermic man can father a child provided sperm is retrieved from his testes.

Advanced Sperm Selection in the IVF Lab using IMSI & PICSI

Intracytoplasmic Morphologically-Selected Sperm Injection better known as IMSI for its acronym in English is a laboratory technique used in IVF treatments (IVF) and involves inserting selected sperm into the egg.

IMSI is a real-time method where sperm is selected before the microinjection takes place. This is done using an inverted microscope that is able to provide much greater magnifying power (around 6000 times) than that normally used in reproductive laboratories (400 times) to carry out ICSI. With this microscope, Biologists can see the internal morphology of sperm and discard those with abnormalities. Being able to select sperm without morphological alterations is believed to increase the chances of successful implantation of the pre-embryo and decrease the likelihood of miscarriage.This technique still requires more study to demonstrate its efficacy and validity in order to be used routinely in the assisted reproduction laboratory and to be recommended with sufficient scientific evidence.

IMSI may improve the chances of fertilization in vitro and can be used if you have performed several unsuccessful In Vitro Fertilization attempts.

During ICSI, the selected sperm should have the perfect morphology (shape), excellent motility as well as be mature. A PICSI dish is a technique, which has ensured that only the top quality sperm are selected. This technique involves using a substance called Hyaluronic Hydrogel, which mimics the binding surface of an egg. Only the functionally competent sperms bind to this and from these “good” sperms, the ones to be used for ICSI are selected.

Assisted Hatching of Embryos (AH)

Embryos implant only when they hatch out from their shell and when the endometrium of the uterus is healthy enough to encourage implantation. In cases where the embryo’s shell or covering Zona) is hard or very thick, making an opening may help the embryo hatch out and implant.

The process of assisted hatching uses a mechanical needle or a laser beam to create a precise opening in the outer coating allowing the embryo to escape and hatch.
Assisted Hatching may help the patients who suffer from repeated implantation failure (where good quality embryos have failed to implant after three or more IVF cycles) and also those women who are above 39 years of age.

Blastocyst / Embryo Transfer

Embryos naturally reach the uterus after their trip through the fallopian tubes to implant at the stage of Blastocyst development around Day 5 or Day 6. In IVF/ICSI it improves the chances to get pregnant and also helps to decide and calculate the growing potential of embryos. This involves the culture of embryos for 5 days in the incubators in the IVF laboratory to a stage called the Blastocyst. This helps in the selection of embryos most likely to implant, Blastocyst transfer is done in cases where the number of good embryos exceeds three on Day 2 of embryo culture. The concept of embryo quality is a very important one for couples experiencing infertility. With blastocyst embryo transfer, we can transfer fewer embryos, thus reducing risks of a pregnancy with multiple fetuses while keeping overall pregnancy rates high. The wife’s suitability to implementing this protocol will be evaluated by the treating doctor and the senior embryologist.

IVF Lite

In IVF treatment, gonadotropin injections are used to stimulate the ovaries to increase the number of available eggs. Conventional IVF protocols are often inconvenient and associated with side effects.
IVF Lite or Minimal Stimulation IVF has regained favor due to the realization that it is associated with fewer side effects, incurs a lower risk of Ovarian Hyper-Stimulation Syndrome (OHSS), has a lower cost factor per cycle and fair success rates in the age group 35 years & above. Aster IVF offers IVF Lite as a cost-effective and safer alternative to the standard IVF program for women above 35 years of age and/or low ovarian reserve.

What is IVF Lite?
IVF Lite involves a soft stimulation protocol with lesser amount of fertility drugs. When combined with Egg Accumulation using the Cryotech TM Vitrification Technology (ACCU-VIT), it provides a very efficient alternative to conventional IVF. It is designed to retrieve only a few eggs in each ovarian stimulation cycle. Stimulation in this manner has been associated with better quality eggs and hence better quality embryos. In other words, it is a simpler treatment schedule with lower doses of drugs and fewer risks from Multiple Pregnancy and Over-stimulation.

IVF Lite can be used as a treatment method for poor responders, women of age above 35 years and/or with multiple previous conventional IVF failures (Failed-IVF) and Hyper-responders (like patients with PCOS who go repeatedly into Ovarian Hyper-Stimulation). Today, IVF Lite is recommended to almost all women above the age of 35 years requiring IVF/ICSI.

If you’re a woman above 35 years of age or have had previous conventional IVF Failures ( Failed IVF), IVF Lite can be your most suitable treatment options available. To discuss whether IVF Lite is suitable for you as your treatment option discuss it with our fertility experts at Aster IVF.

To submit an inquiry about IVF Lite, fill in the form below and our team of experts will get in touch with you at the earliest.

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Natural Cycle IVF

Natural cycle IVF is a form of in vitro fertilization without the use of medication to stimulate the ovary to produce multiple eggs. It is done in a natural menstrual cycle, where only one dominant follicle with a single oocyte (egg) typically develops. Patients are monitored with several ultrasounds and blood tests to follow the development of the single follicle. With Natural Cycle IVF, your body naturally selects your best egg. When mature, the egg is retrieved. It is then fertilized with your husband’s sperm using modern In Vitro Laboratory techniques. If a viable dividing embryo is produced, it is transferred back to the uterus. Two weeks after that, we test for pregnancy.

The entire process is based on your menstrual cycle and takes 30 days. You have no hospitalization, no drugs, and almost no chance of multiple pregnancies, all of which minimize stress.

This process is simple, less stressful, cost-effective and allows you to accommodate your cycle in your hectic work schedule.

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